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Reaction conditions: cyclo-l-Trp-l-Trp DKP (100 mg, 268.51 μmol, 1.00 equiv), bromide (10, 14, 17–20) (537.02 μmol, 2.0 equiv) in acetic acid (0.05 M).
Isolated yield after purification by column chromatography.
dr and regioisomeric ratio calculated yield and 1H NMR analysis.
Mono- and dibenzylation ratio determined by 1H NMR analysis. RT = 25 °C.
