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. 2020 Nov 29;8(3):247–258. doi: 10.1093/nop/npaa079

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© The Author(s) 2020. Published by Oxford University Press on behalf of the Society for Neuro-Oncology and the European Association of Neuro-Oncology. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

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Figure 2. — Case of peri-device and peri-resection cavity changes. MRI brain left-side T1 post-contrast and right-side perfusion-weighted imaging. (Row A) Peri-device changes (left) sagittal image Ommaya reservoir (yellow arrow) with enhancement along catheter (red arrows), without elevated rCBV (red oval) (right), described as possible disseminating necrotizing leukoencephalopathy (DNL) vs peri-device associated inflammation secondary to ICI, no concern for malignancy. (Row B) Peri-resection cavity changes (left) axial image with diffuse linear enhancement along the cavity (yellow arrows) without nodularity or associated elevated rCBV (right). (Row C) (left) axial image with continued progression of enhancement with increased nodularity (yellow arrows) around resection cavity and mild elevation of rCBV (white arrowheads) on perfusion study (right)—likely combined treatment-related encephalitis and tumor progression.