Table 1.
Cohort Characteristics
| Variable | Level | % (N) | Mean ± SD (Range) |
|---|---|---|---|
| Age at surgery | Continuous | 100 (282) | 62 ± 12.9 (19.8-93.1) |
| TT-SRS (days) | Continuous | 100 (282) | 34.6 ± 11.5 (10-82) |
| No. of fractions | Continuous | 100 (282) | 4.5 ± 1.3 (1-6) |
| Radiation dose (cGy) | Continuous | 100 (282) | 2783.7 ± 379.1 (1500-3000) |
| Dose per fraction | Continuous | 100 (282) | 722 ± 402.3 (500-2100) |
| No. of lesions irradiated simultaneously | Continuous | 100 (282) | 1.9 ± 1.3 (1-10) |
| Max diameter | Continuous | 100 (282) | 3.2 ± 1.2 (0.9-6.8) |
| Sex | Female | 60 (170) | |
| Male | 40 (112) | ||
| KPS | 40 | 0 (1) | |
| 50 | 2 (6) | ||
| 60 | 4 (10) | ||
| 70 | 15 (41) | ||
| 80 | 34 (96) | ||
| 90 | 44 (124) | ||
| 100 | 1 (4) | ||
| Primary site histology | NSCLC | 34 (97) | |
| Breast | 16 (44) | ||
| Melanoma | 13 (36) | ||
| RCC | 3 (8) | ||
| GI | 13 (38) | ||
| Ovarian | 5 (14) | ||
| Endometrial | 3 (9) | ||
| Sarcoma | 3 (8) | ||
| Thyroid | 3 (8) | ||
| Prostate | 2 (5) | ||
| Urothelial | 1 (3) | ||
| Squamous cell | 1 (3) | ||
| Cholangiocarcinoma | 0 (1) | ||
| Other/unknown | 3 (8) | ||
| Index lesion lobe | Cerebellar | 21 (58) | |
| Frontal | 35 (98) | ||
| Occipital | 12 (33) | ||
| Parietal | 22 (62) | ||
| Temporal | 11 (31) | ||
| Index lesion laterality | Left | 46 (131) | |
| Right | 54 (151) | ||
| Presenting symptom | Asymptomatic | 10 (28) | |
| Headache/nausea | 18 (50) | ||
| Weakness | 17 (49) | ||
| Speech | 7 (20) | ||
| Seizures | 12 (33) | ||
| Parietal/sensory | 9 (26) | ||
| AMS | 10 (27) | ||
| Unsteadiness/dizziness | 13 (37) | ||
| Visual changes | 3 (8) | ||
| Other | 1 (4) | ||
| Systemic disease at DOS | Stable | 50 (140) | |
| Progressive | 50 (142) | ||
| Recurrence between surgery and SRS | No | 94 (264) | |
| Yes | 6 (18) | ||
| Wound complication | No | 99 (278) | |
| Yes | 1 (4) | ||
| Extent of resection | GTR | 94 (266) | |
| STR | 6 (16) |
Abbreviations: KPS, Karnofsky Performance Status; NSCLC, non-small cell lung cancer; GI, gastrointestinal; AMS, altered mental status; DOS, date of surgery; RCC, Renal Cell Carcinoma; SRS, stereotactic radiosurgery; GTR, Gross total resection; STR, Subtotal resection.