Table 2.
Association of Variables With TT-SRS
| Unadjusted | ||||||
|---|---|---|---|---|---|---|
| Level | N | % | Estimate | 95% CI | P Value | |
| Age at SRS | Continuous | 282 | 100 | 0.06 | −0.04, 0.17 | .23 |
| KPS | Continuous | 282 | 100 | −0.008 | −0.14, 0.13 | .91 |
| Max diameter | Continuous | 282 | 100 | 0.72 | −0.43, 1.86 | .22 |
| No. of lesions irradiated simultaneously | Continuous | 282 | 100 | −1.62 | −2.61, −0.63 | .002 |
| Any recurrence between surgery and postoperative SRS | No | 264 | 94 | ref | ||
| Yes | 18 | 6 | 6.17 | 0.68, 11.66 | .03 | |
| Sex | Female | 170 | 60 | ref | ||
| Male | 112 | 40 | −1.00 | −3.76, 1.77 | .48 | |
| Primary site histology | NSCLC | 97 | 34 | ref | ||
| Breast | 44 | 16 | −1.32 | −5.47, 2.83 | .53 | |
| Melanoma | 36 | 13 | −1.41 | −5.87, 3.04 | .53 | |
| GI | 38 | 13 | 0.44 | −3.93, 4.81 | .84 | |
| Other/unknown | 67 | 24 | 0.47 | −3.16, 4.09 | .80 | |
| Index lesion lobe | Cerebellar | 58 | 21 | ref | ||
| Frontal | 98 | 35 | −1.54 | −5.31, 2.24 | .42 | |
| Occipital | 33 | 12 | −2.40 | −7.37, 2.57 | .34 | |
| Parietal | 62 | 22 | −1.03 | −5.19, 3.14 | .63 | |
| Temporal | 31 | 11 | −2.88 | −7.96, 2.19 | .26 | |
| Index lesion laterality | Left | 131 | 46 | ref | ||
| Right | 151 | 54 | −0.67 | −3.39, 2.04 | .63 | |
| Presenting symptom | Asymptomatic | 28 | 10 | ref | ||
| Headache, N/V | 50 | 18 | −0.79 | −6.18,4.60 | .77 | |
| Weakness | 49 | 17 | 1.17 | −4.24, 6.58 | .67 | |
| Speech | 20 | 7 | 0.70 | −5.99, 7.39 | .84 | |
| Seizures | 33 | 12 | 1.22 | −4.65, 7.09 | .68 | |
| Parietal/sensory | 26 | 9 | −3.90 | −10.12, 2.32 | .22 | |
| AMS | 27 | 10 | 1.06 | −5.09, 7.22 | .73 | |
| Unsteadiness | 37 | 13 | −0.64 | −6.36, 5.08 | .83 | |
| Visual changes/other | 12 | 4 | −2.50 | −10.38, 5.38 | .53 | |
| Systemic disease at DOS | Stable | 140 | 50 | ref | ||
| Progressive | 142 | 50 | −1.87 | −4.57, 0.83 | .17 | |
| Systemic control at DOS | Stable | 115 | 41 | ref | ||
| Progressive | 104 | 37 | −2.36 | −5.41, 0.68 | .13 | |
| Slow | 63 | 22 | 2.54 | −0.99, 6.06 | .16 | |
| GTR vs STR | GTR | 266 | 94 | ref | ||
| STR | 16 | 6 | −3.64 | −9.48, 2.20 | .22 | |
| LOSa | Continuous | 279 | 100 | 1.27 | 0.71, 1.84 | <.0001 |
| Urgent care visits | Continuous | 282 | 100 | 9.09 | 6.05, 12.13 | <.0001 |
| Disposition | Home | 258 | 91 | ref | ||
| Acute rehabilitation | 8 | 3 | 13.36 | 5.40, 21.33 | .001 | |
| Subacute rehabilitation | 15 | 5 | 6.31 | 0.42, 12.21 | .04 | |
| Inpatient hospice | 1 | 0 | −12.89 | −35.12, 9.35 | .25 | |
| New postoperative deficit | No | 250 | 89 | ref | ||
| Yes | 32 | 11 | 1.70 | −2.57, 5.97 | .43 |
Abbreviations: SRS, stereotactic radiosurgery; KPS, Karnofsky Performance Status; NSCLC, non-small cell lung cancer; GI, gastrointestinal; N/V, nausea/vomiting; AMS, altered mental status; DOS, date of surgery LOS, length-of-stay; GTR, gross total resection; STR, subtotal resection.
aExcludes three patients treated with inpatient SRS prior to discharge.