Table 1.

Clinical characteristics of the 10 patients with metastatic glioblastoma or gliosarcoma

Patient number	Age	Gender	Primary tumor histological diagnosis	Metastatic tumor histological diagnosis	Site of glioblastoma	Radiographic feature	Surgery, # craniotomies	Radiation	Chemotherapy	CSF shunt	Metastatic sites	Symptoms of metastatic site	MGMT methylation	IDH-1/2 mutation	Time to Met (mo)	Met to death (mo)	OS (mo)	Surgical complications	Sequenced Site
1	73	M	GBM	Gliosarcoma	Frontal	Cystic, solid, +CE, +hem	+, 2	+	TMZ, PDL-1i, Bev, Carmustine	−	Dura	None	−	−	5.2	6.0	11.2		Brain (primary); dura (met)
2	39	M	GBM	Gliosarcoma	Frontal	Cystic, solid, +CE, +hem	+, 1	+	TMZ, Bev	−	Spine, lung, liver, iliac bone	Low back pain	+	−	11.1	1.0	12.1		Brain (primary)
3	41	M	GBM	GBM	Temporal	Cystic, solid, +CE, +hem	+, 2	+	None	−	Cervical lymph nodes	Neck pain	Unknown	−	10.4	2.0	12.4	Pseudo- meningocele	Brain (primary); LN (met)
4	35	M	GBM/ gliosarcoma	GBM/ gliosarcoma	Temporal	Unavailable	+, 2	+	Gliadel, TMZ	−	Sacrum	Back pain	Unknown	Unknown	12.1	5.6	17.7		Brain (primary)
5	44	F	GBM	GBM	Parietal	Unavailable	+, 2	+	TMZ	−	T7-8 dura, spinal cord, leptomeninges	Progressive paraparesis and ascending thoracic sensory loss	Unknown	Unknown	21.5	3.1	24.6		Not sequenced
6	28	M	GBM	GBM	Frontoparietal	Cystic, solid, +CE	+, 3	+	Nivo, TMZ, Bev, Lomustine, Carbo, Etoposide	−	Vertebrae and femurs	Back pain	−	R132H	32.5	5.0	37.5		Brain (primary); brain (recurrence); brain (recurrence); sacrum (met)
7	23	F	GBM	Poorly differentiated high-grade glioma	Occipital	Cystic, solid, +CE	+, 1	+	TMZ	−	Sacrum, L5 vertebra, hip	Low back pain	−	Unknown	41.4	16.1	57.5		Vertebrae (met); vertebrae (met)
8	14	M	GBM	Poorly differentiated high-grade glioma	Frontotemporal	Cystic, solid, +CE, +hem	+, 3	+	TMZ, MEKi, Bev	+	Lung, skin, thoracic lymph nodes	Pain, shortness of breath	Unknown	Unknown	18.3	2.4	20.7		Brain (recurrence)
9	36	M	GBM	GBM	Frontal	Unavailable	+, 2	+	TMZ	−	Humerus	Shoulder pain	Unknown	Unknown	19.2	25+#	44+#		Not sequenced
10	52	F	GBM	GBM with primitive neuroectodermal tumor-like component	Temporal	Cystic, solid, +CE	+, 2	+	TMZ, Bev	−	Subdural region	Headache	−	Unknown	13.0	6.6	19.6		Brain (primary); dura (met)

IDH, isocitrate dehydrogenase; Met, metastasis; OS, overall survival; CE, contrast enhancement; hem, hemorrhage; TMZ, temozolomide, PDL-L1, programmed cell death ligand 1 inhibitor; Bev, bevacizumab; Nivo, nivolumab; Carbo, carboplatin; MEKi, mitogen-activated protein kinase inhibitor.