Table. Widely accepted nomenclature for HRSV genes and proteins and gene annotation of strains HRSV A2 and HRSV B1*.
| Gene or genome region |
Proteins |
Open reading frame genome position, nt |
||||||
|---|---|---|---|---|---|---|---|---|
| Annotation† | Genome position, nt† |
|||||||
| Strain A2‡ | Strain B1¶ | Annotation | Abbreviation | Strain A2 | Strain B1 | |||
| Leader region |
1–44 |
1–44 |
|
|
|
|
|
|
| NS1 | 45–576 | 45–577 | Nonstructural protein 1 | NS1 | 99–518 | 99–518 | ||
| NS2 |
596–1098 |
594–1098 |
|
Nonstructural protein 2 |
NS2 |
|
628–1002 |
626–1000 |
| N | 1126–2328 | 1125–2327 | Nucleoprotein | N | 1141–2316 | 1140–2315 | ||
| P | 2330–3243 | 2331–3244 | Phosphoprotein | P | 2347–3072 | 2348–3073 | ||
| M | 3253–4210 | 3254–4208 | Matrix protein | M | 3262–4032 | 3263–4033 | ||
| SH | 4220–4629 | 4218–4630 | Small hydrophobic protein | SH | 4304–4498 | 4303–4500 | ||
| G | 4674–5596 | 4675–5600 | Attachment glycoprotein | G | 4689–5585 | 4690–5589 | ||
| F |
5649–7551 |
5653–7552 |
|
Fusion glycoprotein |
F |
|
5662–7386 |
7666–7390 |
| M2 |
7598–8558 |
7609–8568 |
|
Matrix protein 2 | ||||
| Matrix protein M2–1 | M2–1 | 7607–8191 | 7618–8205 | |||||
| Matrix protein M2–2 |
M2–2 |
|
8160–8432 |
8171–8443 |
||||
| L |
8491–15068 |
8501–15080 |
|
Polymerase protein |
L |
|
8499–14996 |
8509–15009 |
| Trailer region | 15069–15223 | 15081–15225 | ||||||
*HRSV, human respiratory syncytial virus. †Nucleotide annotations for leader and trailer region, and for indicated HRSV genes from the first nucleotide of the gene start signal [GGGGCAAAT(A/G); GGAGCAAAAT in case of the L gene] through the last adenosine residue of the gene end signal [AGT(T/A)A(T/A/G)(A/T)(A/T)(A/T)An]. ‡HRSV/A/USA/A2/2015 (45); GenBank accession number KT992094. ¶HRSV/B/USA/B1/1985/B1 (46); GenBank accession number AF013254.1.