Table 1. Clinical definitions in study of melioidosis in children, Brazil, 1989–2019*.

Term	Definition
Suspected melioidosis	All patients with suspected melioidosis must have epidemiologic exposure at any time, recent or not, associated with >1 of the following criteria: acute febrile illness and respiratory symptoms suggestive of community pneumonia that do not improve with conventional antimicrobial treatment (β-lactam antimicrobial drugs); febrile disease that progresses with systemic inflammatory response syndrome, severe sepsis, or septic shock; prolonged fever of unknown etiology or signs and symptoms similar to tuberculosis that do not respond to tuberculosis treatment; or soft tissue infection (e.g. cutaneous ulcers/abscesses, cellulite, or fasciitis) of chronic evolution (i.e. months) with no response to conventional antimicrobial treatment (e.g. oxacillin, ampicillin associated to sulbactam, or cefalexin).
Confirmed melioidosis	All patients with confirmed melioidosis must meet laboratory (bacteriologic confirmation by microbiological culture or positive PCR) or clinical-epidemiologic criteria (exposure to the same risk situation as patients with laboratory-confirmed melioidosis). Patients with confirmed melioidosis must have signs and symptoms that are compatible with melioidosis and not attributable to a different cause.
Severe disease	Patients with severe melioidosis have clinical signs and symptoms and a high risk for death caused by pneumonia, sepsis, or septic shock.

*These criteria were defined by references (5,7).