Table 1. Patient demographics and clinical characteristics of children infected with macrolide-sensitive and macrolide-resistant strains of Mycoplasma pneumoniae, Ohio, USA, 2015–2019*.
| Characteristic | MRMp, n = 12 | MSMp, n = 332 | p value |
|---|---|---|---|
| Sex | 0.9046 | ||
| M | 7 (55) | 175 (53) | |
| F |
5 (45) |
157 (47) |
|
| Year | 0.6508 | ||
| 2015 | 4 (33) | 146 (44) | |
| 2016 | 1 (8) | 51 (15) | |
| 2017 | 2 (17) | 52 (16) | |
| 2018 | 5 (42) | 73 (22) | |
| 2019 |
0 |
10 (3) |
|
| Age, y, mean (SD) |
9.13 (3.74) |
8.73 (4.62) |
0.7683 |
| Previous visits | |||
| Any previous visits | 8 (67) | 188 (57) | 0.4901 |
| No. previous visits, median (IQR) |
1.5 (1–2) |
1 (1–2) |
0.3491 |
| Underlying conditions | 6 (50) | 139 (42) | 0.5752 |
| Chronic immunosuppression | 1 (8) | 5 (2) | 0.1392 |
| Up to date in vaccines |
12 (100) |
316 (97) |
>0.9999 |
| Inpatient | 6 (50) | 130 (39) | 0.551 |
| Median duration of hospitalization, d (IQR) |
8 (6–10) |
2 (1.5–3) |
0.0132
|
| PICU | 3 (25) | 21 (6) | 0.0433 |
| Median duration of PICU stay, d (IQR) |
2 (1–8) |
2 (1.5–5) |
0.8596 |
| Hypoxemia | 3 (25) | 73 (23) | >0.9999 |
| Median duration of O2 support, d (IQR) | 4 (1–8.5) | 1 (0.5–2) | 0.1302 |
| Mechanical ventilation |
1 (33) |
6 (8) |
0.2487 |
| Median duration of symptoms, d (IQR) |
7 (6.5–13) |
7 (5–10) |
0.3324 |
| Fever | 11 (92) | 271 (81) | 0.7024 |
| Median duration of fever, d (IQR) | 4 (2–7) | 4 (2–7) | 0.984 |
| Median maximum temperature, °C (IQR) |
38.4 (38.1–39.4) |
39.1 (38.4–39.7) |
0.0415
|
| Fatigue | 5 (42) | 91 (27) | 0.3298 |
| Decreased appetite/oral food intake | 4 (33) | 125 (38) | >0.9999 |
| Decreased urine output | 0 | 22 (7) | >0.9999 |
| Cough | 12 (100) | 320 (96) | >0.9999 |
| Shortness of breath/respiratory distress | 5 (42) | 91 (27) | 0.3268 |
| Sore throat | 0 | 67 (20) | 0.1332 |
| CNS manifestation | 2 (17) | 10 (3) | 0.0607 |
| Nausea/vomiting | 1 (8) | 55 (17) | 0.6987 |
| Diarrhea | 1 (8) | 30 (9) | >0.9999 |
| Rash | 0 | 25 (7.5) | >0.9999 |
*Values are no. (%) except as indicated. Bold type indicates statistical significance. CNS, central nervous system; IQR, interquartile range; MRMp, macrolide-resistant Mycoplasma pneumoniae; MSMp, macrolide-sensitive Mycoplasma pneumoniae; PICU, pediatric intensive care unit.