Table. Patient characteristics and postmortem data for investigation of rapid antigen test for postmortem evaluation of SARS-CoV-2 carriage, Graz, Austria*.
| Characteristic | RAT cohort, n = 30 | Culture cohort, n = 11 |
|---|---|---|
| Age, y, median (range) |
78 (62–93) |
79 (65–93) |
| Sex, no. (%) | ||
| M | 14 (47.7) | 6 (56) |
| F |
16 (53.3) |
5 (45.4) |
| Disease duration,† d, median (range) | 12 (1–43) | 9 (3–34) |
| Postmortem interval‡, h, median (range) |
22 (8–124) |
25 (14–68) |
| qRT-PCR positive, no. (%) |
24 (80) |
11 (100) |
| Ct value, median (range) | ||
| E gene | 22.8 (14.1–37.3) | 19.9 (13.7–36.0) |
| N gene |
26.9 (18.0–34.6) |
24.6 (17.3–33.7) |
| Cultivation positive, no. (%) |
NA |
7 (63.6) |
| RAT positive, no. (%) |
17 (56.7%) |
NA |
| Total RAT specificity (95% CI§), n = 30 |
100% (61%–100%) |
NA |
| RAT sensitivity (95% CI§), n = 30 | 70.8% (50.8%–85.1%) | NA |
| Total, n = 30 | ||
| Ct <35,¶ n = 23 | 73.9% (53.5%–87.5%) | NA |
| Ct <30,¶ n = 18 | 94.4% (74.2%–99.7%) | NA |
| Ct <25,¶ n = 16 | 100% (80.6%–100%) | NA |
*Ct, cycle threshold; E, envelope; N, nucleocapsid; NA, not applicable; qRT-PCR, quantitative reverse transcription PCR: RAT, rapid antigen test; SARS-CoV-2, severe acute respiratory syndrome coronavirus 2. †Interval from first positive (antemortem) SARS-CoV-2 PCR to death. ‡Interval from death to specimen sampling. §Determined via the hybrid Wilson/Brown method (10). ¶Determined via E gene qRT-PCR.