Table 1. Antiviral Activity and Cytotoxicity of Synthesized Compounds against CHIKV-NanoLuc in BHK-21 Cells.
| code | EC50 (μM) | CC50 (μM) |
|---|---|---|
| D27a | NAb | <0.1 |
| D119a | 32.0 | >100 |
| D127a | 29.6 | >100 |
| D159a | >100 | >100 |
| D160a | 10.5 | >100 |
| D160a | 26.8 | >100 |
| D160b | 70.7 | >100 |
| D160c | 8.7 | >100 |
| D160d | 4.8 | >100 |
| D161a | 13.9 | >100 |
| D162a | 95.9 | >100 |
| D163a | NAb | 10 |
| D164a | 50.5 | >100 |
| D165a | >100 | >100 |
| D166a | NAb | >100 |
a
Compounds were tested as equimolecular mixtures of four possible stereoisomers.
b
NA: inactive, that is, no activity at the maximum nontoxic concentration.