Table 4. Percentage of PANC-1Cell Survival Studies with SAHA Derivatives.
concentrations |
||||||
---|---|---|---|---|---|---|
entry | 3.125 μM | 6.25 μM | 12.5 μM | 25.0 μM | 50.0 μM | IC50 (μg/mL) |
4a | 90.76 ± 0.95 | 83.52 ± 0.54 | 75.77 ± 1.06 | 63.93 ± 0.87 | 58.42 ± 0.72 | 57.08 |
4b | 92.61 ± 0.46 | 84.88 ± 0.59 | 76.86 ± 0.73 | 64.87 ± 0.63 | 57.67 ± 0.78 | 55.66 |
4c | 93.78 ± 1.27 | 85.69 ± 0.19 | 74.36 ± 0.49 | 67.58 ± 0.23 | 63.92 ± 0.57 | 67.21 |
4d | 94.42 ± 0.78 | 88.69 ± 0.65 | 81.93 ± 0.52 | 76.58 ± 0.37 | 72.66 ± 0.48 | 218.16 |
4e | 99.91 ± 0.85 | 96.33 ± 0.56 | 94.25 ± 0.79 | 92.18 ± 0.83 | 89.71 ± 0.65 | 258.74 |
4f | 99.41 ± 0.38 | 97.75 ± 0.54 | 96.13 ± 0.42 | 94.76 ± 0.37 | 91.85 ± 0.59 | 332.59 |
4g | 98.02 ± 0.55 | 91.15 ± 0.73 | 89.60 ± 0.41 | 88.04 ± 0.39 | 85.50 ± 0.65 | 221.08 |
4h | 95.71 ± 0.48 | 91.58 ± 0.43 | 89.13 ± 0.37 | 88.01 ± 0.62 | 86.05 ± 0.53 | 262.37 |
4i | 99.54 ± 0.75 | 95.69 ± 0.66 | 90.47 ± 0.62 | 88.89 ± 0.59 | 85.97 ± 0.79 | 188.16 |
4j | 97.33 ± 0.98 | 93.67 ± 0.87 | 89.43 ± 0.76 | 84.69 ± 0.65 | 79.54 ± 0.93 | 129.54 |
4k | 88.15 ± 0.65 | 82.26 ± 0.48 | 74.86 ± 0.35 | 66.52 ± 0.39 | 54.92 ± 0.52 | 54.31 |
4l | 99.87 ± 0.63 | 93.14 ± 0.87 | 87.28 ± 0.74 | 82.27 ± 0.35 | 77.54 ± 0.72 | 110.24 |