Table 1. Michaelis–Menten Constants of CYP1 Enzyme-Catalyzed Oxidation Reactions^a.

	CYP1A1			CYP1A2			CYP1B1
compound	Km	Vmax	Vmax/Km	Km	Vmax	Vmax/Km	Km	Vmax	Vmax/Km
13	10.7 (2.6–18.7)b	32 (18–46)	3.0	20.3 (0–53)	6.0 (0–12.8)	0.29	7.8 (3.0–2.6)	6.9 (4.7–9.2)	0.89
14	15.6 (10.5–20.6)	2.5 (2.1–2.9)	0.16		NAc			LAd
15	2.11 (0.17–4.1)	4.0 (3.0–5.0)	1.9	2.4 (1.8–3.1)	29.8 (27.5–32.2)	12.3	0.53 (0–1.1)	0.29 (0.25–0.34)	0.55
16	4.8 (2.6–6.9)	12.6 (10.6–14.6)	2.6	0.96 (0.61–1.32)	4.4 (4.1–4.8)	4.6		LA
17	1.04 (0.65–1.42)	7.5 (7–8.1)	7.2	2.2 (1.6–2.8)	8.7 (8–9.4)	4.0		LA
18	9.7 (4.8–14.6)	4.2 (3.3–5.1)	0.43	7.9 (5.1–10.6)	9.1 (7.8–10.5)	1.2		LA
19	0.96 (0.4–1.52)	24.2 (19.4–29)	25.2	0.27 (0.19–0.36)	8.2 (7.6–8.9)	30.4	0.43 (0.24–0.61)	9.3 (8.2–10.4)	21.6
20	0.41 (0.26–0.55)	6.5 (5.9–7.1)	16	2 (1.2–2.7)	1.2 (1.1–1.4)	0.6	0.095 (0.04–0.15)	5.1 (4.7–5.5)	53
21		LA		7.6 (0.59–14.6)	1 (0.63–1.38)	0.13		LA
22		LA			LA		1.1 (0.5–1.7)	1.1 (0.96–1.2)	1.0
23		LA		47 (8–86)	0.4 (0.19–0.6)	0.0085		LA
24	11.9 (0–25.1)	26.2 (14.5–38)	2.21	7.7 (1.4–14)	2.0 (1.4–2.6)	0.26	120 (0–282)	1.75 (0–3.54)	0.015
25	0.054 (0.035–0.075)	10.3 (9.3–11.4)	191	0.56 (0.44–0.68)	3.2 (2.9–3.6)	5.8	0.096 (0.072–0.119)	3.3 (3.0–3.6)	34
26	0.74 (0.54–0.94)	1.35 (1.19–1.50)	1.82	0.93 (070–1.17)	0.25 (0.22–0.28)	0.27	2.59 (1.65–3.53)	0.37 (0.28–0.46)	0.14

^aUnits are μM for K_m, mol/(min·mol CYP) for V_max, and ML/(min·mol CYP) for V_max/K_m.

^b95% confidence interval.

^cNA, no activity was observed.

^dLA, low screening activity at the 20 μM substrate and 25 nM CYP concentration.