Table 1. Specialized Metabolite Biosynthetic Gene Clusters Predicted in the Genome of S. scabiei Using antiSMASH 5.0.
| BGC | BGC type | start | stop | length (bp) | most similar known clustera (% similarity)b | MIBiG ID |
|---|---|---|---|---|---|---|
| 1 | NRPS | 122 258 | 207 140 | 84 883 | pyochelin (73%) | BGC0001801 |
| 2 | betalactone | 210 499 | 245 699 | 35 201 | esmeraldin (8%) | BGC0000935 |
| 3 | NRPS | 331 948 | 400 458 | 68 511 | cadaside A/B (28%) | BGC0001968 |
| 4 | lanthipeptide | 402 211 | 422 773 | 20 563 | labyrinthopeptin A1/A2/A3 (60%) | BGC0000519 |
| 5 | terpene | 561 366 | 581 352 | 19 987 | ebelactone (5%) | BGC0001580 |
| 6 | terpene | 602 733 | 628 185 | 25 453 | isorenieratene (100%) | BGC0001456 |
| 7 | lanthipeptide, bacteriocin | 958 523 | 983 885 | 25 363 | informatipeptin (100%) | BGC0000518 |
| 8 | butyrolactone | 1 354 553 | 1 365 035 | 10 483 | lactonamycin (5%) | BGC0000238 |
| 9 | terpene | 1 445 117 | 1 469 780 | 24 664 | hopene (92%) | BGC0000663 |
| 10 | siderophore | 2 067 195 | 2 079 101 | 11 907 | grincamycin (8%) | BGC0000229 |
| 11 | NRPS-like | 2 214 965 | 2 255 782 | 40 818 | s56-p1 (11%) | BGC0001764 |
| 12 | terpene | 2 273 305 | 2 294 341 | 21 037 | geosmin (100%) | BGC0001181 |
| 13 | bacteriocin | 2 343 879 | 2 354 292 | 10 414 | unknown | |
| 14 | terpene | 2 615 998 | 2 636 826 | 20 829 | FD-594 (8%) | BGC0000222 |
| 15 | siderophore | 2 789 747 | 2 799 722 | 9976 | unknown | |
| 16 | NRPS | 3 581 513 | 3 645 548 | 64 036 | thaxtomin A (50%) | BGC0000444 |
| 17 | T2PKS | 4 831 093 | 4 903 608 | 72 516 | spore pigment (83%) | BGC0000271 |
| 18 | T1PKS, NRPS | 4 907 595 | 4 958 875 | 51 281 | herboxidiene (2%) | BGC0001065 |
| 19 | lanthipeptide | 5 327 434 | 5 350 019 | 22 586 | unknown | |
| 20 | bottromycin, bacteriocin | 6 301 273 | 6 323 906 | 22 634 | bottromycin A2 (54%) | BGC0000469 |
| 21 | siderophore | 6 440 983 | 6 452 205 | 11 223 | desferrioxamine B/E (66%) | BGC0000940 |
| 22 | melanin | 6 584 191 | 6 592 550 | 8360 | melanin (80%) | BGC0000909 |
| 23 | T1PKS, butyrolactone | 6 949 013 | 7 031 953 | 82 941 | 4-hexadecanoyl-3-hydroxy-2-(hydroxymethyl)-2H-furan-5-one (54%) | BGC0000140 |
| 24 | ectoine | 7 828 037 | 7 838 435 | 10 399 | ectoine (100%) | BGC0000853 |
| 25 | NRPS-like | 8 050 515 | 8 093 153 | 42 639 | granaticin (5%) | BGC0000227 |
| 26 | terpene | 8 147 349 | 8 166 320 | 18 972 | unknown | |
| 27 | T1PKS, indole | 8 700 909 | 8 763 617 | 62 709 | 5-isoprenylindole-3-carboxylate/β-D-glycosyl ester (28%) | BGC0001483 |
| 28 | T1PKS | 8 793 628 | 8 848 502 | 54 875 | lasalocid (22%) | BGC0001648 |
| 29 | T3PKS | 8 870 608 | 8 911 792 | 41 185 | daptomycin (10%) | BGC0000336 |
| 30 | terpene | 9 109 516 | 9 130 190 | 20 675 | unknown | |
| 31 | T1PKS | 9 288 913 | 9 413 896 | 124 984 | concanamycin A (89%) | BGC0000040 |
| 32 | siderophore | 9 430 360 | 9 443 981 | 13 622 | unknown | |
| 33 | NRPS | 9 526 250 | 9 591 840 | 65 591 | scabichelin (100%) | BGC0000423 |
| 34 | terpene | 9 618 596 | 9 639 636 | 21 041 | formicamycins A-M (4%) | BGC0001590 |
a
BGCs for which the associated specialized metabolite(s) were annotated in the metabolomic experiments are indicated in bold font.
b
% Similarity represents the percentage of genes in the query cluster which are present in the hit BGC from MIBiG.