Figure 4.

Crystal structure of the GvDTR–GvFdx1 complex. A, Ribbon diagram of the GvDTR homodimer with the subunits in green and grey, each bound to an Fdx colored in magenta and blue, respectively. GvFdx1 has a plant-type Fdx fold and contains a [2Fe-2S] cluster. B, Electron density maps around FAD and Fe-S. The [2Fe-2S] cluster, coordinated by four Cys, is placed at the surface of the protein and close to the interface between GvDTR and GvFdx1 (A). The FAD cofactor, the [2Fe-2S] cluster and the side chain of amino acids Trp³¹⁵, and Cys of the CxxC motif and participating in cluster coordination are shown as sticks.