Table 2. Example of Deorphanization Prediction from DISAE Ensemble Models.
orphan receptor (uniprot ID) | Pfam | drug | drug target |
---|---|---|---|
A0A0C4DFX5 | PF13853 | Isoetharine | ADRB1, ADRB2 |
A0A126GVR8 | PF13853 | Ganirelix | GNRHR |
A0A1B0GTK7 | PF00001 | Levallorphan | OPRM1 |
A0A1B0GVZ0 | PF00001 | Xamoterol | ADRB1, ADRB2 |
A0A286YFH6 | PF13853 | Degarelix | GNRHR |
A3KFT3 | PF13853 | Degarelix | GNRHR |
C9J1J7 | PF00001 | Levallorphan | OPRM1 |
C9JQD8 | PF00001 | Lixisenatide | GLP1R |
E9PH76 | PF00001 | Ganirelix | GNRHR |
E9PPJ8 | PF13853 | Xamoterol | ADRB1, ADRB2 |