Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Interactions between folate and active site residues and solvent molecules. The H-bond distances are shown as dashed lines and are given in Å. Water molecules are numbered according to the water molecules modeled in the neutron structure (i.e., W47 = DOD47). Note the H+ atom triangulated between the Met20 side chain, W47, and the substrate N5 atom. This is based on the modeled deuteron in the pH 4.5 neutron structure.
