Table 2. Representative List of the Known MFS Transporter Structures^a.

MFS family	TCDB	protein	organism	conformation	ligand bound	resolution	PDB	ref
sugar porter	2.A.1.1	XylE	E. coli	outward-occluded	d-glucose	1.50 Å	4GBZ	Sun et al., 2012177
drug:H+ antiporter	2.A.1.2	EmrD	E. coli	occluded		3.50 Å	2GFP	Yin et al., 2006178
organophosphate:Pi antiporter	2.A.1.4	GlpT	E. coli	inward-open		3.30 Å	1PW4	Huang et al., 200317
oligosaccharide:H+ symporter	2.A.1.5	LacY	E. coli	inward-open	TDG	3.60 Å	1PV7	Abramson et al., 200316
fucose:H+ symporter	2.A.1.7	FucP	E. coli	outward-open	n-nonyl-β-d-glucopyranoside	3.14 Å	3O7Q	Dang et al., 2010179
nitrate/nitrite porter	2.A.1.8	NarU	E. coli	partially inward-open occluded		2.80 Å	4IUP	Yan et al., 2013180
phosphate:H+ symporter	2.A.1.9	PipT	Piriformospora indica	inward-occluded	phosphate	2.90 Å	4J05	Pedersen et al., 2013181
monocarboxylate transporter	2.A.1.13	SfMCT	S. fumaroxidans	outward-open	l-lactate	2.69 Å	6HCL	Bosshart et al., 2019182
organic anion:cation symporter	2.A.1.14	DgoT	E. coli	inward-open	d-gluconic acid	2.91 Å	6E9N	Leano et al., 2019183
proton-dependent oligopeptide transporter	2.A.17	PepTSo	S. oneidensis	inward-occluded		3.62 Å	2XUT	Newstead et al., 2011159
glycoside-pentoside-hexuronide:cation symporter	2.A.2.1	MelB	S. typhimurium	outward-partially occluded		3.35 Å	4M64	Ethayathulla et al., 2014184
equilibrative nucleoside transporter	2.A.57	ENT1	H. sapiens	outward-open	dilazep	2.30 Å	6OB7	Wright and Lee, 201928
ferroportin	2.A.100	ferroportin	Bdellovibrio bacteriovorus	outward-open	potassium	2.20 Å	5AYN	Taniguchi et al., 2015185
atypical SLC	2.A.1.2	MFSD10 (TETRAN)	H. sapiens	outward-open		2.40 Å	6S4M	unpublished

^aThe first determined structure in each family is shown.