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. 2021 Mar 11;121(8):4561–4677. doi: 10.1021/acs.chemrev.0c00752

Figure 30.

Figure 30

High-throughput microfluidic platforms. (A) Standard multiwell plate based-microfluidics. (a) Sliced tissue culture system for drug screening. Reprinted with permission from ref (679). Copyright 2014 Royal Society of Chemistry. (b) Multiwell plate-based 3D cell culture platform with 40 culture chambers. Reprinted with permission from ref (677). Copyright 2013 Royal Society of Chemistry. (c) A 384 hanging drop spheroid culture array plate. Reprinted with permission from ref (680). Copyright 2011 Royal Society of Chemistry. (B) Microstructure-based cell culture array. (a) Microfluidic cell culture unit for long-term cellular monitoring. Reprinted with permission from ref (636). Copyright 2005 Wiley-VCH. (b) Microfluidic device containing thousands of cell traps for cell capture and pairing. Scale bar, 20 μm. Reprinted with permission from ref (705). Copyright 2009 Nature Publishing Group. (C) Valve-assisted microfluidic platforms. (a) Integration of 96 parallel cell culture chambers on a chip. Reprinted and modified with permission from ref (638). Copyright 2007 American Chemical Society. (b) Microfluidic living cell array. Reprinted with permission from ref (728). Copyright 2007 Royal Society of Chemistry. (D) Droplet-based microfluidics. (a) Microfluidic channel array for droplet immobilization. Scale, 40 μm. Reprinted with permission from ref (734). Copyright 2009 Royal Society of Chemistry. (b) Microfluidic droplet printer for dispensing programmed combinations of cells and reagents on the substrate. Reprinted with permission from ref (737). Copyright 2017 National Academy of Sciences.