Skip to main content
. 2021 Mar 11;121(8):4561–4677. doi: 10.1021/acs.chemrev.0c00752

Figure 33.

Figure 33

Cell culture in 3D matrices in microfluidic chips. (A) Compartmentalization. (a) Microfluidic chip for hepatocyte 3D culture and multiple drug testing. Reprinted with permission from ref (664). Copyright 2009 Royal Society of Chemistry. (b) Microfluidic device for constructing a neural circuit in 3D. Scale bar 200 μm. Reprinted with permission from ref (669). Copyright 2016 Wiley-VCH. (c) Microfluidic 3D blood capillary model using BMA-EDMA-supported hydrogel patterning. Scale bar 50 μm. Reprinted with permission from ref (670). Copyright 2018 Wiley-VCH. (B) Patterning using sacrificial elements. Fabrication process to create microfluidic channels within collagen gels (top). Photos show a device design, a fabricated device, and DAPI stained-HUVECs culture in the channel (bottom). Reprinted with permission from ref (768). Copyright 2013 Royal Society of Chemistry. (C) Molding. (a) Fabrication of PDMS/PEG-hydrogel microfluidic networks. Reprinted with permission from ref (777). Copyright 2010 Elsevier, Ltd. (b) Schematic fabrication process of hydrogel microfluidic device by a twice-cross-linking technique. Reprinted with permission from ref (772). Copyright 2018 Wiley-VCH.