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. 2021 Mar 11;121(8):4561–4677. doi: 10.1021/acs.chemrev.0c00752

Table 4. Multiparameter Gradients and Corresponding Parameters.

multiparameter gradient parameters ref
linear double gradient composition: the gradients range from 25–100% PLLA (254)
roughness: starting from the PDLLA-rich end, surface roughness increased as the fraction of PLLA increased; roughness then reached a plateau between 60 and 80% PLLA before becoming somewhat smoother from 80–100% PLLA
wettability: 30–94° (145)
stiffness: 85 MPa to ∼7 MPa
orthogonal gradient pore size: ranging from hundreds to tens of nanometers (255)
peptide density: not shown
dual topography gradient: on one axis varied from 8–100 μm space between the 8 μm grooves and on the other axis from ∼5 nm to ∼1 μm in depth (256)
topography: the groove width ranging from 5–95 μm with a constant ridge depth of 3.4 μm (257)
chemistry: varying from a hydrocarbon to a nitrogen-containing polymer
topography: parallel grooves with widths varying from 5–95 μm, separated by 5 μm wide ridges (253)
wettability: WCA ranging from 55–96°
roughness: Ra value ranging from 0.8–4.1 μm (31)
nanoparticle density: particle number decreased linearly from around 74 particles per μm2 to 0
constant groove width of 8 μm and with ridge width increasing from 8 μm in 0.5 μm steps across 10 mm (33)
gradient of groove depth spanning more than 2 orders of magnitude (less than 10 nm to over 1000 nm)
peptide concentration gradient: GRGDS concentrations ranging from ∼15–90 pmol/cm2 and BMP-2 concentration range from ∼0–25 pmol/cm2 (258)
stiffness: 6–89 MPa (146)
WCA: 29–90°
stiffness: 0.5–1.3 kPa (259)
Fn: a roughly 5-fold difference between the highest and lowest densities