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. 2021 Mar 11;121(8):4561–4677. doi: 10.1021/acs.chemrev.0c00752

Table 7. Overview of Popular Simulation Tools.

tool description programming language license development mode website
COPASI software application for simulation and analysis of biochemical networks and their dynamics C, SMBL open source GUI + code-based http://copasi.org/
VCell VCell, (Virtual Cell) is a comprehensive platform for modeling cell biological systems that is built on a central database and disseminated as a web application. VCell Math description language, SBML open source GUI + code-based https://vcell.org/
COMPUCELL3D COMPUCELL3D is a software framework for three-dimensional (3D) simulation of morphogenesis in different organisms that uses a stochastic cellular potts model (CPM) and PDE solvers. C++ open source GUI-based http://www.compucell3d.org/
FLAME FLAME is a generic agent-based modeling system XML open source GUI-based http://flame.ac.uk/
FreeFEM FreeFEM is a partial differential equation solver for nonlinear multiphysics systems in 2D and 3D C++ open source code-based; many algorithms implemented https://freefem.org/
FEBIO FEBio software suite is a set of software tools for nonlinear finite element analysis in biomechanics and biophysics C++ open source GUI-based https://febio.org/
Comsol Multiphysics a cross-platform finite element analysis, solver, and multiphysics simulation software. Comsol language closed source GUI-based https://www.comsol.com/
MATLAB is a multiparadigm numerical computing environment and proprietary programming language developed by MathWorks. MATLAB; can interface with programs written in C++, Java, R, and Python closed source code-based; many inbuilt algorithms https://nl.mathworks.com/?s_tid=gn_logo
GNU Octave (alternative for MATLAB) GNU Octave is a high-level language, primarily intended for numerical computations Octave open source code-based https://www.gnu.org/software/octave/