Table 2. EC50 Values for Compounds Active in the S. mansoni Schistosomula Roboworm Assaya.
EC50 in S. mansoni schistosomula Roboworm assay
(μM) |
||
---|---|---|
compound | phenotype | motility |
9 OX03144 | 28.4 | 28.0 |
25 OX03146 | 25.5 | 25.6 |
15 OX03596 | 29.1 | 26.8 |
34 OX03599 | 14.2 | 18.3 |
17 OX03601 | 24.4 | 20.6 |
36 OX03698 | 28.5 | 26.6 |
6 OX03707 | 32.7 | 29.3 |
22 OX03824 | 40.9 | 36.8 |
35 OX03828 | 25.7 | 20.7 |
Compounds were screened at 10, 20, 30, 40, and 50 μM, and EC50 values were calculated for each of the screening parameters, phenotype, and motility.