Table 1. Antimicrobial Activity of Zidovudine and Efavirenz Tested against 35 Isolates of E. coli, 20 Isolates of E. faecalis, 22 Isolates of Bacteroides spp., and 10 Isolates of Prevotella spp. by Broth Dilution Method.
| antibacterial
effect of Zidovudine | |||
|---|---|---|---|
| strains | aMIC50 (mg/L) | bMIC90 (mg/L) | susceptibility (%) |
| E. coli | 0.5 | 1 | 100 |
| Bacteroides spp. | 4 | 8 | 75 |
| Prevotella spp. | 4 | 8 | 70 |
| E. faecalis | >128 | >128 | 0 |
| antibacterial effect of Efavirenz | |||
|---|---|---|---|
| E. coli | >256 | >256 | 0 |
| Bacteroides spp. | 16 | 128 | 70 |
| Prevotella spp. | 16 | 32 | 100 |
| E. faecalis | 16 | 32 | 100 |
a
MIC50 and
b
MIC90 are defined as the minimal concentration of drug capable of inhibiting 50% and 90% of the isolates tested, respectively.