Figure 1.

Synthesis of PEG-corona PISA-derived nanoparticles. (A) Synthesis of PEG₄₅-b-PDAAm_n diblock copolymer nanoparticles via aqueous RAFT-mediated PISA using a commercially available PEG₄₅ macro-CTA ([solids] = 10% w/w, [NaCl] = 0.05 M). (B) Normalized SEC RI molecular weight distributions. M_n,SEC and Đ_M values were calculated from PMMA standards with DMF + 5 mM NH₄BF₄ as the eluent. (C) Evolution of M_n (black circles) and Đ_M (red circles) values with increasing targeted DP_PDAAm. (D) Zeta potential values for PEG₄₅-b-PDAAm_n diblock copolymer nanoparticles. (E) Representative dry-state images of PEG₄₅-b-PDAAm_n diblock copolymer nanoparticles, stained with 1 wt % uranyl acetate (UA) solution. (F) Intensity-weighted size distributions along with average D_h and PD values (the error shows the standard deviation from five repeat measurements).