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. 2021 May 4;143(19):7449–7461. doi: 10.1021/jacs.1c01963

Figure 4.

Figure 4

Summary of PISA formulation using non-PEG-based coronas. (A) Synthesis of PVP40-b-PDAAmn diblock copolymer nanoparticles via aqueous RAFT/MADIX-mediated PISA. PVP40 macro-CTA was synthesized by photoinitiated RAFT polymerization ([solids] = 20% w/w, [NaCl] = 0.05 M). (B) Representative dry-state TEM images of PVP40-b-PDAAmn diblock copolymer nanoparticles, stained with 1 wt % uranyl acetate (UA) solution. (C) Normalized intensity-weighted size distributions obtained by DLS. (D) Zeta potential values for PVP40-b-PDAAmn diblock copolymer nanoparticles. (E) Synthesis of PDMAC40-b-PDAAm200 diblock copolymer vesicles via aqueous RAFT-mediated PISA using a PDMAC40 macro-CTA ([solids] = 20% w/w, [NaCl] = 0.05 M). (F) (i) Representative dry state and (ii) cryo-TEM images; (iii) intensity-weighted size distribution along with average Dh and PD values (the error shows the standard deviation from five repeat measurements). Inset: autocorrelation function.