Table 1. Through-Space Coupling Constants of Compounds 1a–p.
| compound | R1 | R2 | J (Hα, F) (Hz) | J (Cα, F) (Hz) |
|---|---|---|---|---|
| 1a | –CH(CN)2 | –H | 3.21 | 10.54 |
| 1b | –CH(CN, CO2Et) | –H | 3.28 | 10.11 |
| 1c | –CH2CH3 | –H | 3.20 | 6.70 |
| 1d(12) | –H | –H | 5.03 | 7.71 |
| 1e(8) | –Br | –H | 3.20 | 9.63 |
| 1f(13) | –CH3 | –H | 3.20 | 7.71 |
| 1g(14) | –CO2CH2CH3 | –H | 3.66 | 8.67 |
| 1h(15) | –H | 4′-Br | 5.03 | 6.74 |
| 1i(16) | –H | 5′-Br | 5.03 | 7.71 |
| 1j(17) | –H | 4′-OH | 5.03 | 7.71 |
| 1k(18) | –H | 4′-F | 5.03 | 7.71 |
| 1l(19) | –H | 4′,5′-F | 5.03 | 7.71 |
| 1m(20) | –H | 5′-NO2 | 5.03 | 6.74 |
| 1n(21) | –H | 4′-OCH3 | 5.03 | 7.71 |
| 1o(22) | –CH3 | 4′-F | 3.20 | 7.71 |
| 1p(23) | –Cl | 4′-F | 3.20 | 11.56 |