Scheme 12. Synthesis of Compounds 39, 40, and 44–46.
Reagents and conditions: (a) DIPEA, 1,4-dioxane, 120 °C, 18 h, 56%; (b) POCl3, 80 °C, 1 h, 67%; (c) (i) Pd/C, H2, MeOH, RT, 18 h; (ii) CDI, DIPEA, DCM, 18 h, then pyrrolidine, RT, 4.5 h, 22–46%.
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