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. 2021 Apr 27;64(9):5905–5930. doi: 10.1021/acs.jmedchem.1c00047

Table 3. Initial Modifications of the Bi-cyclic Core.

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a

INMAC is the intramacrophage assay carried out in THP-1 cells with L. donovani amastigotes. Data are the result of at least three independent replicates and standard deviations are ≤0.4.

b

Cli is the mouse liver microsomal intrinsic clearance.