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Table 3. Initial Modifications of the Bi-cyclic
Core.
a
INMAC is the intramacrophage assay
carried out in THP-1 cells with L. donovani amastigotes. Data are the result of at least three independent replicates
and standard deviations are ≤0.4.
b
Cli is the mouse liver
microsomal intrinsic clearance.