Table 3. Selectivity Data for Bicyclic n-Carboxylic Acids.
| hGPR120 |
hGPR40 |
|||||
|---|---|---|---|---|---|---|
| comp. | EC50a (Ca2+) | EC50 (β-arr) | EC50 (IP1) | EC50 (Ca2+) | EC50 (β-arr) | EC50 (IP1) |
| 23 | -b | - | 63 | - | - | 1828 |
| 24 | - | 24 | 35 | - | - | >10000 |
| 25 | - | 84 | 220 | - | - | >10000 |
| 26 | - | 66 | 98 | - | - | >10000 |
| 27 | 93 | - | - | >100000 | - | - |
| 28 | 740 | - | - | >100000 | - | - |
| 29 | 360 | - | - | >100000 | - | - |
nM.
Data not registered for the referred compound.