Table 2. In Vitro Permeability (P_e) Values with Related Predictive Penetrations into the CNS of Commercial Drugs, 5 and 6.

	BBB penetration estimation
compound	Pe ± SEM (× 10–6 cm/s)a	CNS (+/−)
5	6.99 ± 1.04	CNS +
6	17.70 ± 4.63	CNS +
furosemide	0.19 ± 0.07	CNS –
ranitidine	0.35 ± 0.31	CNS –
donepezil	21.93 ± 2.06	CNS –
tacrine (4a)	5.96 ± 0.59	CNS –

^aP_e ± SEM (n = 3). Each compound was assessed in quadruplicate.