Figure 11.

Distribution of neutral, acid, basic, and zwitterionic SCEs in period A (2000–2011: N = 1038) and period B (2012–2021: N = 980). * To define the acid/base properties of the SCEs, their ionization state at pH 7.4 was considered.

Distribution of neutral, acid, basic, and zwitterionic SCEs in period A (2000–2011: N = 1038) and period B (2012–2021: N = 980). * To define the acid/base properties of the SCEs, their ionization state at pH 7.4 was considered.