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. 2021 Apr 13;64(8):4410–4429. doi: 10.1021/acs.jmedchem.1c00181

Figure 11.

Figure 11

Distribution of neutral, acid, basic, and zwitterionic SCEs in period A (2000–2011: N = 1038) and period B (2012–2021: N = 980). * To define the acid/base properties of the SCEs, their ionization state at pH 7.4 was considered.