Figure 7.
Frequency of elements beyond CHON in SCEs in period A (blue; 2000–2011: N = 1038) and period B (orange; 2012–2021: N = 980). In the INN lists, four molecules are listed as containing sodium, but a visual inspection revealed that this indicates the salified molecule. These molecules were thereby excluded from the figure. Numbers in parentheses refer to the relative ranking of elements in FDA-approved drugs.20 *The occurrence of each element group refers to the number of SCEs containing at least one.