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. 2021 Apr 14;64(9):6241–6261. doi: 10.1021/acs.jmedchem.1c00263

Scheme 6. Synthesis of Target Compounds 23ap and 24al.

Scheme 6

Reagents and conditions: (a) HATU, Et3N, DMF, rt, 12 h; (b) SOCl2, DMF, CH2Cl2, reflux, 3 h; (c) Et3N, DMAP, tetrahydrofuran (THF), rt, 3 h.