Scheme 7. Synthesis of Target Compounds 25a–q.
Reagents and conditions: (a) HATU, Et3N, DMF, rt, 12 h; (b) 1 mol/L LiOH aqueous solution, CH3OH, reflux, 2 h; (c) EDCI, HOBt, Et3N, DMF, rt, 24 h.
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