Table 5. Activity of Selected Compounds in an Intracellular Macrophage Infection Model.
| log10 CFU/macrophagesa |
||||
|---|---|---|---|---|
| compounds | 10 μg/mL | Δlog10 CFUb | 5 μg/mL | Δlog10 CFUb |
| 23j | 4.45 ± 0.03 | 1.07 | 4.54 ± 0.01 | 0.98 |
| 24f | 4.18 ± 0.04 | 1.34 | 4.41 ± 0.10 | 1.11 |
| 25a | 4.77 ± 0.10 | 0.75 | 5.06 ± 0.03 | 0.46 |
| 25b | 4.59 ± 0.05 | 0.93 | 4.75 ± 0.21 | 0.77 |
| 25l | 4.54 ± 0.00 | 0.98 | 4.59 ± 0.03 | 0.93 |
| TCA1 | 4.36 ± 0.08 | 1.16 | 4.91 ± 0.19 | 0.61 |
| RFP | 4.49 ± 0.11 | 1.03 | ||
| untreated | 5.52 ± 0.18 | 5.52 ± 0.18 | ||
a
log10 CFU against M. tuberculosis (H37Rv) in infected mouse J774A.1 macrophages.
b
Δlog10 CFU = log10 CFU (untreated) – log10 CFU (treated with the selected compounds).