Table 7. Mouse PK Properties of Compounds 24f, 25a, and TCA1.

		24f		25a		TCA1
parameters	units	p.o.	i.v.	p.o.	i.v.	p.o.	i.v.
dose	mg/kg	50	5	50	5	50	5
t1/2a	h	1.70	0.13	0.85	0.26	2.19	0.47
tmax	h	1.00		0.58		1.00
Cmax	ng/mL	25.4	1299	486	4555	10 603	14 304
AUC0–t	ng·h/mL	41.9	183	651	830	33 715	7910
AUC0–∞b	ng·h/mL	57.9	184	657	833	33 724	7912
MRT0–∞c	h	2.10	0.13	1.10	0.20	2.87	0.39
clearance	mL/(min·kg)		479		101		10.6
Fd	%	2.3		7.9		42.6

^aPlasma elimination half-life.

^bPlasma exposure.

^cMean residence time.

^dOral bioavailability.