Table 8. In Vivo Efficacy of Compound 25a.
compounds | Dose (mg/kg) | log10 CFU/lung | log10 CFU/lung | Δlog10 CFUa |
---|---|---|---|---|
untreated | 6.44 ± 0.34 | 7.10 ± 0.15 | ||
INH | 25 | 1.76 ± 0.49 | 1.93 ± 0.21 | 4.68/5.17 |
TCA1 | 100 | 4.24 ± 0.25 | 2.86 | |
25a | 100 | 4.42 ± 0.45 | 2.02 |
Δlog10 CFU = log10 CFU (untreated) – log10 CFU (treated with selected compounds).