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. 2021 Apr 14;64(9):6241–6261. doi: 10.1021/acs.jmedchem.1c00263

Table 8. In Vivo Efficacy of Compound 25a.

compounds Dose (mg/kg) log10 CFU/lung log10 CFU/lung Δlog10 CFUa
untreated   6.44 ± 0.34 7.10 ± 0.15  
INH 25 1.76 ± 0.49 1.93 ± 0.21 4.68/5.17
TCA1 100   4.24 ± 0.25 2.86
25a 100 4.42 ± 0.45   2.02
a

Δlog10 CFU = log10 CFU (untreated) – log10 CFU (treated with selected compounds).