. 2021 Mar 25;64(7):3508–3545. doi: 10.1021/acs.jmedchem.0c01808

Table 10. (Top) IC₅₀ Values Compounds 103 and 104 against Various 3Cpro and 3CLpro Using FRET-Based Enzyme Assays and (Bottom) EC₅₀ Values of Compounds 103 and 104 against Various Viruses in the Cell-Based Assays and CC₅₀ (Concentration That Causes 50% Cell Death) Values^a.

cpd	NV [μM]	MD145 [μM]	HRV [μM]	SARS-CoV [μM]
103	0.14 ± 0.2	0.51 ± 0.2	0.15 ± 0.05	0.23 ± 0.1
104	2.6 ± 1.5	3.1 ± 1.6	0.12 ± 0.2	0.61 ± 0.2

cpd	NV [μM]	MNV-1 [μM]	HRV18 [μM]	coronavirus 229E [μM]	CC₅₀ [μM]
103	0.04 ± 0.02	0.6 ± 0.2	0.015 ± 0.03	0.2 ± 0.1	87 ± 6.3
104	4.2 ± 2.4	0.03 ± 0.04	0.03 ± 0.04	0.5 ± 0.2	>100

Data are taken from Prior et al.¹⁸⁹

Table 10. (Top) IC50 Values Compounds 103 and 104 against Various 3Cpro and 3CLpro Using FRET-Based Enzyme Assays and (Bottom) EC50 Values of Compounds 103 and 104 against Various Viruses in the Cell-Based Assays and CC50 (Concentration That Causes 50% Cell Death) Valuesa.