Table 3. Biological Activity of HIV-1 Attachment Inhibitors 48–55a.
cpd | EC50 [nM] | CC50 [μM] |
---|---|---|
48 | 86 ± 24 (LAI) | 145 ± 23 |
49 | 4.0 (JR-FL) | 200 |
4.9 (LAI) | ||
50 | 1.52 (JR-FL) | >300 (n = 2) |
51 | 575.9 (JR-FL) | >300 (n = 2) |
52 | 21.6 (JR-FL) | >300 (n = 2) |
53 | 1.7 ± 1.6 (JR-FL, n = 11) | 280 |
54 | 1.47 ± 0.63 (JR-FL) | >300 |
2.68 ± 1.64 (LAI) | ||
55 | 0.88 ± 0.46 (JR-FL, n = 56) | >300 |
1.15 (LAI) |