Table 3. Biological Activity of HIV-1 Attachment Inhibitors 48–55a.
| cpd | EC50 [nM] | CC50 [μM] |
|---|---|---|
| 48 | 86 ± 24 (LAI) | 145 ± 23 |
| 49 | 4.0 (JR-FL) | 200 |
| 4.9 (LAI) | ||
| 50 | 1.52 (JR-FL) | >300 (n = 2) |
| 51 | 575.9 (JR-FL) | >300 (n = 2) |
| 52 | 21.6 (JR-FL) | >300 (n = 2) |
| 53 | 1.7 ± 1.6 (JR-FL, n = 11) | 280 |
| 54 | 1.47 ± 0.63 (JR-FL) | >300 |
| 2.68 ± 1.64 (LAI) | ||
| 55 | 0.88 ± 0.46 (JR-FL, n = 56) | >300 |
| 1.15 (LAI) |
