Table 9. IC50 and EC50 Values of Compounds 103–106 from NV 3CLpro Fluorescence Resonance Energy Transfer (FRET)-Based Assay and NV Replicon Cells, Respectivelya.
cpd | IC50 [μM] | EC50 [μM] |
---|---|---|
103 | 0.14 ± 0.2 | 0.04 ± 0.02 |
104 | 2.6 ± 1.5 | 4.2 ± 2.4 |
105 | 0.24 ± 0.1 | 0.04 ± 0.03 |
106 | 35.5 ± 5.7 | 0.1 ± 0.3 |
Data taken from Prior et al.189