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. 2021 Mar 25;64(7):3508–3545. doi: 10.1021/acs.jmedchem.0c01808

Table 9. IC50 and EC50 Values of Compounds 103106 from NV 3CLpro Fluorescence Resonance Energy Transfer (FRET)-Based Assay and NV Replicon Cells, Respectivelya.

3.2.1.

cpd IC50 [μM] EC50 [μM]
103 0.14 ± 0.2 0.04 ± 0.02
104 2.6 ± 1.5 4.2 ± 2.4
105 0.24 ± 0.1 0.04 ± 0.03
106 35.5 ± 5.7 0.1 ± 0.3
a

Data taken from Prior et al.189