Table 1.
Binding interactions/functions of SWI/SNF subunits and their role in cancer.
| Complex | SWI/SNF subunits (genes) | Domainsa | Chromatin interaction | SWI/SNF-associated cancer |
|---|---|---|---|---|
| BAF/PBAF/ncBAF | BRG1 (SMARCA4) | ATPase, helicase, bromodomain BRK, HSA, QLQ, SnAC [130] | DNA binding, histone binding | Breast cancer, cutaneous cancer, B-cell lymphoma, bladder carcinoma, non-small cell lung cancer, melanoma, glioma carcinoma, |
| BRM (SMARCA2) | ATPase, helicase, bromodomain, BRK, HSA, QLQ, SnAC | DNA binding, histone binding | Ovarian small cell carcinoma, sarcoma, lung adenocarcinoma, hepatocellular carcinoma | |
| BAF53A (ACTL6A) | Actin-like | Not reported | Squamous cell carcinoma, rhabdomyosarcoma | |
| SS18* (SS18) | No domain annotation | Not reported | Synovial sarcoma, Ewing sarcoma | |
| β-actin (ACTB) | Armadillo repeats | Not reported | Abnormal expression and polymerisation of ACTB in most cancers leading to changes of the cytoskeleton associated with invasiveness and metastasis [133]. | |
| BAF155 (SMARCC1) | Chromodomain, SWIRM, SANT | Histone binding | Rhabdoid cancer, small cell lung caner | |
| BAF170§ (SMARCC2) | Chromodomain, SWIRM, SANT | Histone binding | Gastric cancer, colorectal cancer, rhabdoid cancer, pancreatic cancer | |
| BCL7 (A, B or C) (BCL7A, B or C) | Conserved N-terminal domain | Not reported | Multiple myeloma, non-Hodgkin lymphoma | |
| BAF60 (A, B§ or C#) (SMARCD1,2 or 3) | SWIB | Not reported | Lung cancer, gastric cancer | |
| BAF57§ (SMARCE1) | HMG box | DNA binding | Breast cancer, endometrial carcinoma, ovarian carcinoma, meningioma | |
| BAF47§ (SMARCB1) | Winged helix DNA-binding domain [34, 35] | DNA binding, nucleosome acidic patch binding | Malignant rhabdoid tumour, prostate cancer, renal medullary carcinoma, epithelioid sarcoma, familial schwannomatosis | |
| BAF | BAF250 (A or B) (ARID1A or B) | ARID (AT-rich interactive domain) | DNA binding | Ovarian clear cell carcinoma, uterine endometrial cancer, neuroblastoma, colorectal cancer |
| BAF45 (B, C or D) (DPF1,2 or 3) | Zinc finger/PHD finger | Histone binding | Colorectal cancer | |
| PBAF | BAF200 (ARID2) | ARID, RFX winged helix DBD, zinc finger | DNA binding | Melanoma, non-small cell lung cancer, hepatocellular carcinoma, colorectal carcinoma |
| BRD7 (BRD7) | Bromodomain, DUF3512 | Histone binding | Hepatocellular carcinoma, nasopharyngeal carcinoma, lung cancer, ovarian carcinoma | |
| BAF180 (PBRM1) | Bromodomain, BAH domain, HMG box | DNA binding, histone binding | Clear cell renal cell carcinoma | |
| BAF45A (PHF10) | PHD finger | Histone binding | Gastric cancer | |
| ncBAF | BRD9 (BRD9) | Bromodomain, DUF3512 | Histone binding | Nut midline carcinoma, rhabdoid cancer |
| GLTSCR1 (BICRA) | No annotation | Not reported, BRD4 interactor | Glioma tumour, prostate cancer | |
| GLTSCR1L (BICRAL) | No annotation | Not reported, BRD4 interactor | Prostate cancer |
aSelected domains annotated in UniProt or the indicated reference. *Found only in BAF and ncBAF. §Found only in BAF and PBAF. #Found only in BAF.