Table 1.
Antibacterial susceptibility (MIC, μg ml−1) and ribosomal affinity IC50 (μg ml−1) studies of synthesized compounds
| Compounds | M. tuberculosis H37Rv MIC (µg ml−1) | S. pneumoniae R6 MIC (μg ml−1) | E. coli K-12 MIC (µg ml−1) | E. coli cellular accumulation (µM) | Ribosome translation inhibition IC50 (μg ml−1) |
|---|---|---|---|---|---|
|
Spectinomycin (1) |
50 | 12.5 | 25 | 1.1 ± 0.1 | 0.36 |
|
2 |
1.6 | 12.5 | 200 | 5.4 ± 0.8 | 0.89 |
|
3 |
6.25 | 3.13 | 50 | 40 + 1 | 0.74 |
|
4 |
1.6 | 12.5 | 100 | 5.9 + 0.8 | 0.84 |
|
5 |
>200 | >200 | >200 | 2.3 + 0.4 | >60 |
|
6 |
50 | 25 | >200 | 10.0 + 0.6 | 9.50 |
|
7 |
100 | 25 | >200 | 47 + 1 | 23.3 |
|
8 |
>200 | >200 | >200 | 1.29 ± 0.06 | 54.7 |
|
9 |
>200 | >200 | >200 | <0.4 | >60 |
|
10 |
200 | 50 | >200 | 5.6 ± 0.5 | 10.2 |
|
11 |
100 | >200 | >200 | 1.77 ± 0.06 | 34.7 |
