Table 4. Comparison of Corrected Free Energies of Hydration from AMOEBA at 298 K to TCPD Estimates Obtained using a Proton Free Energy of Hydration of −258.26 kcal/mol.

side chain	corrected AMOEBA kcal/mol (I)	TCPD estimates kcal/mol (II)	residuals I–II kcal/mol
Arg+	–53.39 ± 0.11	–53.13	–0.26
Lys	–66.98 ± 0.10	–65.88	+1.10
Asp	–84.63 ± 0.08	–83.34	+1.29
Glu	–81.08 ± 0.12	–81.98	–0.90