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. Author manuscript; available in PMC: 2022 Jun 1.
Published in final edited form as: J Invest Dermatol. 2020 Dec 30;141(6):1493–1502. doi: 10.1016/j.jid.2020.11.025

Table 3:

Multi-Variable Mendelian Randomization

Approach Psoriasis + BMI on T2D T2D + BMI on Psoriasis
Num. Markers Psoriasis BMI Num. Markers T2D BMI
OR P OR P OR P OR P
Established (p<5x10−8) loci IVW (standard) 548 1.01 0.528 2.73 4.84x10−73 650 1.06 0.095 1.37 1.44x10−4
MR-Egger 1.01 0.506 2.73 7.70x10−73 1.06 0.096 1.37 1.59x10−4
MR-RAPS 1.02 0.363 2.60 2.07x10−70 1.04 0.215 1.35 4.49x10−4
Genome-wide information IVW (standard) 3,749 1.01 1.59x10−4 2.59 3.07x10−304 3,703 1.05 0.014 1.35 1.40x10−7
MR-Egger 1.01 1.36x10−4 2.59 1.90x10−303 1.05 0.016 1.35 1.64x10−7
MR-RAPS 1.01 0.0128 2.26 1.37x10−174 1.04 0.116 1.29 2.70x10−5

Abbreviations are as follows: IVW, inverse variance weighted; Num., number of; T2D, type 2 diabetes; BMI, body mass index; OR, odds ratio; p, p-value.