. Author manuscript; available in PMC: 2022 Jun 1.

Published in final edited form as: Semin Cell Dev Biol. 2021 Feb 12;114:126–133. doi: 10.1016/j.semcdb.2021.01.002

Table 2.

Lineage plasticity in healthy and tumorigenic mammary glands and potential involvement of SOX factors

Models	Phenotype of mixed-lineage cells	Involvement of SOX factors	Citations
fMaSC-derived organoids	K8⁺/K14⁺	High SOX10 expression	[20,26]
Ablation of luminal cells using K8rtTA/TetO-DTA	CD29^highEpCam^high, co-expression of basal and luminal signatures	Not known	[66]
Activation of Pik3ca^H1047R in basal or luminal cells using K5 or K8 Cre drivers	K5⁺/K8⁺	Not known	[36]
Activation of Pik3ca^H1047R in basal or luminal cells using Lgr5 or K8 Cre drivers	K8/18⁺/K14⁺, acquisition of mammary-repopulating ability	Not known	[34]
Trp53 and Brca1 deletion in luminal cells with Ad-K8-Cre intraductal injection	K5⁺/K8⁺, EMT	Increased SOX9 and SOX4 expression	[35]
Early lesions in C3/Tag mice	K8⁺/K14⁺	Dependent on SOX9 upregulation	[53]
Pten and Trp53 deletion in luminal cells with Elf5 Cre driver	EMT	Not known	[67]