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. Author manuscript; available in PMC: 2022 Jun 1.
Published in final edited form as: J Mol Cell Cardiol. 2021 Mar 3;155:66–77. doi: 10.1016/j.yjmcc.2021.02.014

Fig. 3. Cardiotoxic drug perturbation simulations.

Fig. 3.

A) Predicted dynamics of selected network proteins in response to sorafenib. Change in cardiomyocyte apoptosis network activity following treatment with B) Sorafenib, C) Sunitinib, D) Ponatinib, E) Trastuzumab, F) Gefitinib, G) Nilotinib, and H) Erlotinib. Caspases 3 and 9 are upregulated in response to all treatment conditions, confirming that the model predicts apoptosis for these seven TKIs. I) Change in activity of network proteins Bad, Bax, caspase 9, caspase 3, CAD, and PARP in response to the seven simulated TKI treatments.