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. Author manuscript; available in PMC: 2022 Jun 1.
Published in final edited form as: J Mol Cell Cardiol. 2021 Mar 3;155:66–77. doi: 10.1016/j.yjmcc.2021.02.014

Fig. 6. Functional regulators of TKI-induced apoptosis.

Fig. 6.

A) Knockdown of network species AP1, ASK1, JNK, MEK47, p53, and ROS decreases in sorafenib-induced apoptosis, indicating that these species are positive regulators of apoptosis. B) Top positive regulators of sorafenib-, sunitinib-, ponatinib-, trastuzumab-, gefitinib-, nilotinib-, and erlotinib-induced apoptosis. C) Overexpression of network species Akt, IGF1, PDK1, and PI3K reduces sorafenib-induced apoptosis. D) Top negative regulators (mitigators) of TKI-induced apoptosis.