Table 1. Tyrosine kinase inhibitors (TKIs) modeled in the network and their targets.

Targets incorporated into the network shown in bold. Data on TKI targets was obtained from the DrugBank database.

TKI	Targets
Erlotinib (ERL)	EGFR
Gefitinib (GEF)	EGFR
Nilotinib (NIL)	ABL1, KIT
Ponatinib (PON)	ABL1, BCR, KIT, RET, TEK, FLT3, FGFR1, FGFR2, FGFR3, FGFR4
Sorafenib (SOR)	BRAF, RAF1, VEGFR3, VEGFR2, FLT3, PDGFRB, KIT, FGFR1, RET, VEGFR1
Sunitinib (SUN)	PDGFRB, VEGFR1, KIT, VEGFR2, VEGFR3, FLT3
Trastuzumab (TRAZ)	ERBB2