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. Author manuscript; available in PMC: 2022 Jun 1.
Published in final edited form as: Prostaglandins Other Lipid Mediat. 2021 Mar 19;154:106548. doi: 10.1016/j.prostaglandins.2021.106548

Figure 4. Impact of 20-HETE on the myogenic response of isolated rat Pas.

Figure 4.

A: Comparison of the luminal diameters of the PAs isolated from SD rats in response to increased perfusion pressure with or without HET0016 treatment. Passive diameters were recorded in calcium-free solution. B: Comparison of changes in luminal diameters of the PAs isolated from SD rats in response to HET0016 in the absence or presence of WIT003. C: Comparison of changes in luminal diameters of PAs isolated from SS, SS.BN5, and SS.Cyp4a1 rats. Mean values ± SEM are presented. Numbers in parentheses indicate the number of animals and vessels studied. * indicates P < 0.05 from the corresponding values in control group. † indicates P < 0.05 from the corresponding values of HET0016-treated PAs in the absence or presence of WIT003. ‡ indicates P < 0.05 from the corresponding values of SS rats. PAs, parenchymal arterioles; SD, Sprague Dawley; SS, Dahl salt-sensitive rats; HET0016, N-Hydroxy-N′-(4-butyl-2-methylphenyl)-formamidine; WIT003, 20-hydroxyeicosa-5(Z),14(Z)-dienoic acid.