Table 2:
Diet | Genotype | PFOS (mg/kg) |
Body Weight (g) | Liver Weight (g) | WAT Weight (g) |
---|---|---|---|---|---|
Normal Diet (ND) | Cyp2b-null | 0 | 22.58±0.54p**g** | 0.958±0.024p*** | 0.335±0.014p |
1 | 23.77±0.70g*** | 1.372±0.038g*** | 0.388±0.045 | ||
10 | 18.11±0.37p**g | 1.820±0.12p***b | 0.0382±0.025p | ||
hCYP2B6 | 0 | 23.20±0.55p**g**d** | 0.927±0.022p***g | 0.426±0.058pd*** | |
1 | 23.52±0.50g*** | 1.350±0.027g*** | 0.310±0.025 | ||
10 | 18.51±0.81p**g* | 2.004±0.067p***gd*b | 0.0714±0.022pd* | ||
High Fat Diet (HFD) | 0 | 27.55±1.87p***gd** | 1.066±0.10p*** | 1.358±0.290p***gd*** | |
10 | 20.29±0.70p***g** | 2.250±0.070p***g**d* | 0.260±0.051p***d* |
Data represented as mean +/− SEM. Statistical significance was determined by one-way ANOVA followed by Fisher’s LSD as the post-hoc test.
‘p’ indicates difference between PFOS concentration
‘g’ indicates difference between gender (see Table 3)
‘d’ indicates difference between diet
‘b’ indicated difference between genotype
Letter with no asterisk indicates p < 0.05
indicates p < 0.01
indicates p < 0.001
indicates p < 0.0001.